| Primary Identifier | MGI:88497 | Organism | mouse, laboratory |
| Chromosome | 13 | NCBI Gene Number | 12919 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables corticotropin-releasing hormone binding activity. Involved in several processes, including cellular response to estradiol stimulus; cellular response to organonitrogen compound; and maternal aggressive behavior. Acts upstream of or within hormone metabolic process. Located in extracellular space and nucleus. Is expressed in adrenal gland; central nervous system; eye; hemolymphoid system gland; and lung. Human ortholog(s) of this gene implicated in cocaine dependence; depressive disorder; and heroin dependence. Orthologous to human CRHBP (corticotropin releasing hormone binding protein). PHENOTYPE: Mice homozygous for disruptions in this gene display behavior indicative of increased anxiety. Male mice also show reduced food intake resulting in reduced growth between ages 7 and 15 weeks. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
