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Protein Coding Gene : Mpg N-methylpurine-DNA glycosylase
Primary Identifier  MGI:97073 Organism  mouse, laboratory
Chromosome  11 NCBI Gene Number  268395
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Enables alkylbase DNA N-glycosylase activity. Acts upstream of or within base-excision repair. Predicted to be located in cytosol and nucleoplasm. Is expressed in several structures, including early conceptus; gonad; hemolymphoid system gland; musculature; and placenta. Orthologous to human MPG (N-methylpurine DNA glycosylase).
PHENOTYPE: Homozygotes for a targeted null mutation exhibit impaired base excision repair of alkylation-induced DNA damage, and increased sensitivity to methyl methanesulfonate and streptozoticin-induced diabetes. Mutants are fertile and long-lived. [provided by MGI curators]
  • synonyms:
  • MGI:2144133,
  • Mpg,
  • 3-methyladenine DNA glycosylase,
  • alkylpurine-DNA-N-glycosylase,
  • MGD-MRK-19564,
  • AI326268,
  • Aag,
  • Mid1,
  • N-methylpurine-DNA glycosylase,
  • MGD-MRK-12404,
  • APNG,
  • expressed sequence AI326268
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Genome

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2 Involved In Mutations

Trail: ProteinCodingGene

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0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

7 Pathways

Trail: ProteinCodingGene

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Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

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