| First Author | Martin FM | Year | 2004 |
| Journal | Sci Aging Knowledge Environ | Volume | 2004 |
| Issue | 32 | Pages | pe32 |
| PubMed ID | 15308771 | Mgi Jnum | J:92901 |
| Mgi Id | MGI:3054709 | Doi | 10.1126/sageke.2004.32.pe32 |
| Citation | Martin FM, et al. (2004) Ticking fast or ticking slow, through Shc must you go?. Sci Aging Knowledge Environ 2004(32):pe32 |
| abstractText | Circumstantial evidence places the p66 isoform of the adapter protein Shc in a position to mediate the accelerated aging phenotype displayed by mice expressing shortened forms of the tumor suppressor protein p53. We present a model in which p66(shc) may be responsible for integrating signals from the p53 pathway with signals from the insulin-like growth factor-1/Daf pathway in mammals. A full understanding of how interactions between p53 and p66(shc) affect longevity will require the production of animals with mutations in the genes encoding both proteins. |
