First Author | Rattner A | Year | 1997 |
Journal | Proc Natl Acad Sci U S A | Volume | 94 |
Issue | 7 | Pages | 2859-63 |
PubMed ID | 9096311 | Mgi Jnum | J:39275 |
Mgi Id | MGI:86658 | Doi | 10.1073/pnas.94.7.2859 |
Citation | Rattner A, et al. (1997) A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors. Proc Natl Acad Sci U S A 94(7):2859-63 |
abstractText | This paper describes the identification of a new family of mammalian genes that encode secreted proteins containing homology to the cysteine-rich ligand-binding domain found in the frizzled family of transmembrane receptors. The secreted frizzled-related proteins (sFRPs) are approximately 30 kDa in size, and each contains a putative signal sequence, a frizzled-like cysteine-rich domain, and a conserved hydrophilic carboxy-terminal domain. The sFRPs are not the products of differential splicing of the known frizzled genes. Glycosylphosphatidylinositol-anchored derivatives of sFRP-2 and sFRP-3 produced in transfected human embryonic kidney cells confer cell-surface binding by the Drosophila Wingless protein. These observations suggest that sFRPs may function in vivo to modulate Wnt signaling, or, alternatively, as novel ligands for as yet unidentified receptors. |