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Allele : Notch1<tm5(cre/ERT2)Rko> notch 1; targeted mutation 5, Raphael Kopan
Primary Identifier  MGI:5009237 Allele Type  Targeted
Attribute String  Inducible, Recombinase Gene  Notch1
Transmission  Germline Strain of Origin  C57BL/6NTac-Tg(HBB-lacZ)ALey/Ley
Induced With  tamoxifen Is Recombinase  true
Is Wild Type  false
molecularNote  The targeting construct was designed to replace exons 29-34 (encoding the intracellular domain) with a CreERT2 sequence and nuclear localization signal, followed immediately downstream by a C-terminal 6xMyc epitope tag, 2xSV40 polyadenylation sequence, and frt-flanked Pgk1/EM7 promoter-driven neomycin selection cassette. The CreER fusion gene (Cre-ERT2) is Cre recombinase fused to a G400V/M543A/L544A triple mutation of the human estrogen receptor ligand binding domain.
  • mutations:
  • Insertion,
  • Intragenic deletion
  • synonyms:
  • NIP1::CreER<T2>,
  • N1::CreERT2,
  • Notch1::CreERT2,
  • Notch1::CreERT2,
  • N1::CreERT2,
  • NIP1::CreER<T2>
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1 Feature

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0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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