| First Author | Karreth FA | Year | 2013 |
| Journal | Cancer Discov | Volume | 3 |
| Issue | 10 | Pages | 1113-21 |
| PubMed ID | 24072616 | Mgi Jnum | J:205054 |
| Mgi Id | MGI:5543962 | Doi | 10.1158/2159-8290.CD-13-0202 |
| Citation | Karreth FA, et al. (2013) ceRNA cross-talk in cancer: when ce-bling rivalries go awry. Cancer Discov 3(10):1113-21 |
| abstractText | The cancer transcriptome is characterized by aberrant expression of both protein-coding and noncoding transcripts. Similar to mRNAs, a significant portion of the noncoding transcriptome, including long noncoding RNAs and pseudogenes, harbors microRNA (miRNA)-response elements (MRE). The recent discovery of competitive endogenous RNAs (ceRNA), natural decoys that compete for a common pool of miRNAs, provides a framework to systematically functionalize MRE-harboring noncoding RNAs and integrate them with the protein-coding RNA dimension in complex ceRNA networks. Functional interactions in ceRNA networks aid in coordinating a number of biologic processes and, when perturbed, contribute to disease pathogenesis. In this review, we discuss recent discoveries that implicate natural miRNA decoys in the development of cancer. SIGNIFICANCE: Cross-talk between ceRNAs through shared miRNAs represents a novel layer of gene regulation that plays important roles in the physiology and development of diseases such as cancer. As cross-talk can be predicted on the basis of the overlap of miRNA-binding sites, we are now one step closer to a complete functionalization of the human transcriptome, especially the noncoding space. |
