| First Author | Chess A | Year | 1994 |
| Journal | Cell | Volume | 78 |
| Issue | 5 | Pages | 823-34 |
| PubMed ID | 8087849 | Mgi Jnum | J:20339 |
| Mgi Id | MGI:68437 | Doi | 10.1016/s0092-8674(94)90562-2 |
| Citation | Chess A, et al. (1994) Allelic inactivation regulates olfactory receptor gene expression. Cell 78(5):823-34 |
| abstractText | We suggest a model in which a hierarchy of controls is exerted on the family of odorant receptor genes to assure that a sensory neuron expresses a single receptor from a family of 1000 genes. We propose that a cis-regulatory element directs the stochastic expression of only one gene from a large array of linked receptor genes. Moreover, only one allelic array encoding multiple receptor genes is active in an individual neuron. We demonstrate that in a neuron expressing a given receptor, expression derives exclusively from one allele. In addition, we observe that alleles encoding the odorant receptors are replicated asynchronously, a phenomenon consistently associated with allelic inactivation. This model, involving inactivation of one allelic array and cis control of the active array, provides a mechanism such that individual neurons express one or a small number of receptors. |
