| First Author | Hashimoto A | Year | 1993 |
| Journal | Neurosci Lett | Volume | 152 |
| Issue | 1-2 | Pages | 33-6 |
| PubMed ID | 8100053 | Mgi Jnum | J:21994 |
| Mgi Id | MGI:66629 | Doi | 10.1016/0304-3940(93)90476-2 |
| Citation | Hashimoto A, et al. (1993) Free D-serine, D-aspartate and D-alanine in central nervous system and serum in mutant mice lacking D-amino acid oxidase. Neurosci Lett 152(1-2):33-6 |
| abstractText | We have examined whether D-amino acid oxidase (DAO) regulates free D-serine content using mutant ddY/DAO- mice lacking DAO activity. We find that the content of D-serine in the serum and cerebellum of mutant mice is much higher than that of normal mice, whereas a slight but significant difference in the cerebral D-serine level is observed between the two strains. These results suggest that, although DAO may participate in the catabolism of D-serine in the cerebellum and periphery, there appears to be other mechanisms for catabolism of endogenous D-serine in the brain. |
