Primary Identifier | IPR028526 | Type | Family |
Short Name | NCK1 |
description | Cytoplasmic protein NCK1 (NCK1) is a non-enzymatic adaptor protein composed of three SH3 (Src homology 3) domains and a C-terminal SH2 domain []. There aretwo vertebrate NCK proteins, NCK1 and NCK2.NCK1 mediates receptor tyrosine kinase signalling and modulates eIF2alphaSer51 phosphorylation by a subset of eIF2alpha kinases [, ]. NCK1 also mediates signalling from the ER membrane compartment []. |