| First Author | Nisitani S | Year | 1993 |
| Journal | J Exp Med | Volume | 178 |
| Issue | 4 | Pages | 1247-54 |
| PubMed ID | 8376932 | Mgi Jnum | J:15380 |
| Mgi Id | MGI:63503 | Doi | 10.1084/jem.178.4.1247 |
| Citation | Nisitani S, et al. (1993) The bcl-2 gene product inhibits clonal deletion of self-reactive B lymphocytes in the periphery but not in the bone marrow. J Exp Med 178(4):1247-54 |
| abstractText | To test whether the product of the bcl-2 proto-oncogene blocks clonal deletion of self-reactive B cells, we have generated transgenic mice carrying the bcl-2 gene and the immunoglobulin genes for the anti-erythrocyte 4C8 antibody. In these transgenic mice, clonal deletion of self-reactive immature B cells in the bone marrow was not inhibited in spite of expression of the bcl-2 gene. In contrast, self-antigen-induced clonal deletion of mature self-reactive Ly-1 B (B1) cells in the peritoneal cavity was inhibited in the transgenic mice. These results indicate that the mechanism for clonal deletion of immature self-reactive B cells in the bone marrow differs from that of mature self-reactive B cells in the periphery. |
