| First Author | Buchberg AM | Year | 1990 |
| Journal | Mol Cell Biol | Volume | 10 |
| Issue | 9 | Pages | 4658-66 |
| PubMed ID | 2167436 | Mgi Jnum | J:10694 |
| Mgi Id | MGI:59141 | Doi | 10.1128/mcb.10.9.4658 |
| Citation | Buchberg AM, et al. (1990) Evi-2, a common integration site involved in murine myeloid leukemogenesis. Mol Cell Biol 10(9):4658-66 |
| abstractText | BXH-2 mice have the highest incidence of spontaneous retrovirally induced myeloid leukemia of any known inbred strain and, as such, represent a valuable model system for identifying cellular proto-oncogenes involved in myeloid disease. Chronic murine leukemia viruses often induce disease by insertional activation or mutation of cellular proto-oncogenes. These loci are identified as common viral integration sites in tumor DNAs. Here we report on the characterization of a novel common viral integration site in BXH-2 myeloid leukemias, designated Evi-2. Within the cluster of viral integration sites that define Evi-2, we identified a gene that has the potential for encoding a novel protein of 223 amino acids. This putative proto-oncogene possesses all of the structural features of a transmembrane protein. Within the transmembrane domain is a leucine zipper, suggesting that Evi-2 is involved in either homopolymer or heteropolymer formation, which may play an important role in the normal functioning of Evi-2. Interestingly, the human homolog of Evi-2 has recently been shown to be tightly linked to the von Recklinghausen neurofibromatosis locus, suggesting a role for Evi-2 in human disease as well. |
