| First Author | Novershtern N | Year | 2008 |
| Journal | Am J Respir Cell Mol Biol | Volume | 38 |
| Issue | 3 | Pages | 324-36 |
| PubMed ID | 17921359 | Mgi Jnum | J:146354 |
| Mgi Id | MGI:3837300 | Doi | 10.1165/rcmb.2007-0151OC |
| Citation | Novershtern N, et al. (2008) A functional and regulatory map of asthma. Am J Respir Cell Mol Biol 38(3):324-36 |
| abstractText | The prevalence and morbidity of asthma, a chronic inflammatory airway disease, is increasing. Animal models provide a meaningful but limited view of the mechanisms of asthma in humans. A systems-level view of asthma that integrates multiple levels of molecular and functional information is needed. For this, we compiled a gene expression compendium from five publicly available mouse microarray datasets and a gene knowledge base of 4,305 gene annotation sets. Using this collection we generated a high-level map of the functional themes that characterize animal models of asthma, dominated by innate and adaptive immune response. We used Module Networks analysis to identify co-regulated gene modules. The resulting modules reflect four distinct responses to treatment, including early response, general induction, repression, and IL-13-dependent response. One module with a persistent induction in response to treatment is mainly composed of genes with suggested roles in asthma, suggesting a similar role for other module members. Analysis of IL-13-dependent response using protein interaction networks highlights a role for TGF-beta1 as a key regulator of asthma. Our analysis demonstrates the discovery potential of systems-level approaches and provides a framework for applying such approaches to asthma. |
