| First Author | Narita T | Year | 2018 |
| Journal | Int Immunol | Volume | 30 |
| Issue | 7 | Pages | 301-309 |
| PubMed ID | 29718261 | Mgi Jnum | J:262448 |
| Mgi Id | MGI:6158071 | Doi | 10.1093/intimm/dxy030 |
| Citation | Narita T, et al. (2018) Mice lacking all of the Skint family genes. Int Immunol |
| abstractText | gammadeltaT cells develop in the thymus and play important roles in protection against infection and tumor development, but the mechanisms by which the thymic microenvironment supports gammadeltaT cell differentiation remain largely unclear. Skint1, a B7-related protein expressed in thymic epithelial cells, was shown to be essential for the development of mouse Vgamma5Vdelta1 gammadeltaT cells. The Skint family in mouse consists of 11 members, Skint1-11. Here we generated mutant mice lacking the entire genomic region that contains all of the Skint genes. These mice exhibited a marked reduction of Vgamma5Vdelta1 gammadeltaT cells in the thymus and skin, but surprisingly, had normal development of other gammadeltaT cell subsets and leukocytes including alphabetaT, B and myeloid cells. This phenotype is essentially identical to that of Skint1-deficient mice. These results indicate that the Skint family exerts an exclusive function in regulating the development of Vgamma5Vdelta1 gammadeltaT cells and is dispensable for development of other leukocytes. |
