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Protein Coding Gene : Glo1 glyoxalase 1
Primary Identifier  MGI:95742 Organism  mouse, laboratory
Chromosome  17 NCBI Gene Number  109801
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Enables lactoylglutathione lyase activity and zinc ion binding activity. Involved in osteoclast differentiation. Acts upstream of or within regulation of transcription by RNA polymerase II. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Is expressed in central nervous system and retina. Human ortholog(s) of this gene implicated in autistic disorder; diabetic retinopathy; end stage renal disease; type 2 diabetes mellitus; and vascular disease. Orthologous to human GLO1 (glyoxalase I).
PHENOTYPE: Mice homozygous for a knock-out allele show accumulation of a methylglyoxal-derived advanced glycation end product in liver and alterations in anxiety- and depression-like behaviors. [provided by MGI curators]
  • synonyms:
  • RIKEN cDNA 2510049H23 gene,
  • glyoxylase 1 regulatory,
  • MGD-MRK-13737,
  • MGI:1918922,
  • glyoxalase 1 regulatory,
  • 1110008E19Rik,
  • glyoxalase 1 complex,
  • RIKEN cDNA 1110008E19 gene,
  • MGD-MRK-10126,
  • MGD-MRK-10124,
  • 2510049H23Rik,
  • Glo-1r,
  • MGD-MRK-10121,
  • MGI:1917563,
  • MGI:95743,
  • glyoxalase 1,
  • Glo1,
  • MGD-MRK-10122,
  • RIKEN cDNA 0610009E22 gene,
  • 0610009E22Rik,
  • Glo1-r,
  • MGI:2147081,
  • Glo1-s,
  • MGD-MRK-10120,
  • Qglo,
  • glyoxalase 1 structural,
  • AW550643,
  • glyoxylase 1 structural,
  • expressed sequence AW550643,
  • Glo-1s,
  • MGI:1913383,
  • MGD-MRK-10125,
  • Glo-1,
  • MGI:95744
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