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Protein Coding Gene : Nme8 NME/NM23 family member 8
Primary Identifier  MGI:1920662 Organism  mouse, laboratory
Chromosome  13 NCBI Gene Number  73412
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Predicted to enable 3'-5' exonuclease activity and microtubule binding activity. Acts upstream of or within cellular response to reactive oxygen species and flagellated sperm motility. Located in axoneme; sperm cytoplasmic droplet; and sperm principal piece. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 6. Orthologous to human NME8 (NME/NM23 family member 8).
PHENOTYPE: Homozygous mutant displays normal reproductive system phenotype [provided by MGI curators]
  • synonyms:
  • RIKEN cDNA 1700056P15 gene,
  • Sptrx-2,
  • Nme8,
  • NME/NM23 family member 8,
  • 1700056P15Rik,
  • Txndc3,
  • thioredoxin domain containing 3 (spermatozoa)
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Features --> Cross References

Genome

Sequence Feature Displayer

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0 Canonical

0 CDSs

0 Exons

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1 Involved In Mutations

Trail: ProteinCodingGene

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0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

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Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

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