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Protein Coding Gene : Map4k2 mitogen-activated protein kinase kinase kinase kinase 2

Primary Identifier  MGI:1346883 Organism  mouse, laboratory
Chromosome  19 NCBI Gene Number  26412
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Predicted to enable ATP binding activity; MAP kinase kinase kinase kinase activity; and mitogen-activated protein kinase kinase kinase binding activity. Involved in vesicle targeting. Predicted to be located in Golgi apparatus and plasma membrane. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human MAP4K2 (mitogen-activated protein kinase kinase kinase kinase 2).
PHENOTYPE: Mice homozygous for a null allele exhibit decreased susceptibility to endotoxin shock. [provided by MGI curators]
  • synonyms:
  • MGD-MRK-37069,
  • RAB8 interacting protein,
  • MGI:2147514,
  • expressed sequence AI385662,
  • Rab8ip,
  • Map4k2,
  • MGI:108033,
  • BL44,
  • AI385662,
  • mitogen-activated protein kinase kinase kinase kinase 2

Features --> Cross References

Genome

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0 Involved In Mutations

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Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

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Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

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