| First Author | Abe C | Year | 1995 |
| Journal | Int J Tissue React | Volume | 17 |
| Issue | 5-6 | Pages | 175-80 |
| PubMed ID | 8835627 | Mgi Jnum | J:34415 |
| Mgi Id | MGI:81874 | Citation | Abe C, et al. (1995) Effects of cytogenin on spontaneous arthritis in MRL/1 mice and on pristane-induced arthritis (PIA) in DBA/1J mice. Int J Tissue React 17(5-6):175-80 |
| abstractText | Cytogenin, 8-hydroxy-3-hydroxymethyl-6-methoxyisocoumarin, has low cytotoxicity on murine and human tumour cells in vitro. It augments or suppresses phagocytosis of macrophages and lymphocyte proliferation. It has been reported that cytogenin has a potent inhibitory effect clinically on adjuvant arthritis in Lewis rats and on type II collagen-induced arthritis in DBA/1J mice. Our experimental findings provide evidence that cytogenin has beneficial effects on spontaneous polyarthritis in MRL/1 mice and pristane-induced arthritis in DBA/1J mice. The results suggest that the mode of the anti-arthritic action of cytogenin is different from those of NSAIDs; although the precise mode of action remains unclear, cytogenin may become an excellent therapeutic agent for rheumatoid arthritis. |
