| First Author | Tinel A | Year | 2004 |
| Journal | Science | Volume | 304 |
| Issue | 5672 | Pages | 843-6 |
| PubMed ID | 15073321 | Mgi Jnum | J:320335 |
| Mgi Id | MGI:6872263 | Doi | 10.1126/science.1095432 |
| Citation | Tinel A, et al. (2004) The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress. Science 304(5672):843-6 |
| abstractText | Apoptosis is triggered by activation of initiator caspases upon complex-mediated clustering of the inactive zymogen, as occurs in the caspase-9-activating apoptosome complex. Likewise, caspase-2, which is involved in stress-induced apoptosis, is recruited into a large protein complex, the molecular composition of which remains elusive. We show that activation of caspase-2 occurs in a complex that contains the death domain-containing protein PIDD, whose expression is induced by p53, and the adaptor protein RAIDD. Increased PIDD expression resulted in spontaneous activation of caspase-2 and sensitization to apoptosis by genotoxic stimuli. Because PIDD functions in p53-mediated apoptosis, the complex assembled by PIDD and caspase-2 is likely to regulate apoptosis induced by genotoxins. |
