| Primary Identifier | IPR001158 | Type | Domain |
| Short Name | DIX |
| description | Proteins of the dishevelled family (Dsh and Dvl) play a key role in thetransduction of the Wg/Wnt signal from the cell surface tothe nucleus: in response to Wnt signal, they block the degradation of beta-catenin by interacting with the scaffolding protein axin. The N terminus ofproteins of the dishevelled family and the C terminus of proteins of the axinfamily share a region of homology of about 85 amino acids, which has beencalled DIX for DIshevelled and aXin []. The DIX domain is found associated with PDZ and DEP domains in proteins of the dishevelled family and with an RGS domain in proteins of the axin family. DIX has been shown to be a protein-protein interaction domain that is important for homo- and hetero-oligomerization of proteins of the dishevelled and axin families [, , , ]. The DIX domain has also be shownto be a signalling module that can target proteins to actinstress fibres andcytoplasmic vesicles to control Wnt signalling [].The Dvl2 DIX domain has been shown to form a predominantly helical structure[].A third type of DIX domain-possessing protein, known as Coiled-coil-DIX1 (Ccd1) or Dixin, forms homomeric and heteromeric complexes with Dvl and Axin and is positive regulator of Wnt signaling []. |
