| First Author | Verschelde C | Year | 2006 |
| Journal | Cell Death Differ | Volume | 13 |
| Issue | 7 | Pages | 1213-21 |
| PubMed ID | 16294210 | Mgi Jnum | J:126130 |
| Mgi Id | MGI:3760580 | Doi | 10.1038/sj.cdd.4401814 |
| Citation | Verschelde C, et al. (2006) Overexpression of the antiapoptotic protein A1 promotes the survival of double positive thymocytes awaiting positive selection. Cell Death Differ 13(7):1213-21 |
| abstractText | As it has been shown for Mcl-1, Bcl-xl and Bcl-2, proteins of the Bcl-2 family play a crucial role during T-cell development in the thymus. We here show that the expression of the antiapoptotic gene A1 is specifically enhanced at the DN3/DN4 transition and in DP thymocytes that have been positively selected suggesting that A1 expression might be considered as a transcriptional signature of thymocytes that have received pre-TCR or TCR survival signal. Furthermore, we observed that A1-a overexpression in recombination activation gene 1-deficient mice transgenic for the major histocompatibillity complex class I-restricted F5 TCR enhances cell survival of DP thymocytes and permits accumulation of DP cells awaiting positive selection. However, A1-a overexpression has no effect on negative selection. Therefore, our results suggest that A1 plays a specialized role in allowing survival of DP thymocytes and that its role can be distinguished from that of Mcl-1, Bcl-xl and Bcl-2. |
