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Protein Coding Gene : Ctrb1 chymotrypsinogen B1
Primary Identifier  MGI:88559 Organism  mouse, laboratory
Chromosome  8 NCBI Gene Number  66473
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0)

Enables serine-type endopeptidase activity. Acts upstream of or within proteolysis. Predicted to be located in extracellular region. Is expressed in ovary; pancreas; pancreas tip epithelium; and testis. Orthologous to human CTRB1 (chymotrypsinogen B1) and CTRB2 (chymotrypsinogen B2).
PHENOTYPE: Mice homozygous for a null allele exhibit increased susceptibility to induced pancreatitis with reduced intrapancreatic chymotrypsin activation. [provided by MGI curators]
  • synonyms:
  • expressed sequence AI504462,
  • pancreatic proteinase 2,
  • Prt-2,
  • 2200008D09Rik,
  • chymotrypsinogen B1,
  • MGD-MRK-2243,
  • MGD-MRK-13634,
  • RIKEN cDNA 2200008D09 gene,
  • MGI:1913723,
  • AI504462,
  • Ctrb1,
  • MGI:2138990
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