| Type | MGI:General | Description | at 8-12 weeks of age, homozygotes display defects in AMPAR-mediated glutamatergic synaptic transmission impaired glutamatergic synapse transmission is accompanied by tiny-headed immature dendritic spines, due to aberrant Rap2 activation in the prefrontal cortex Rap2 inactivation in the mPFC ameliorates the behavioral defects in spatial working memory and enhanced anxiety but has little effect on the cognition defect assessed by the novel object recognition test |
