| First Author | Iwase Y | Year | 2000 |
| Journal | Cancer Lett | Volume | 154 |
| Issue | 1 | Pages | 101-5 |
| PubMed ID | 10799745 | Mgi Jnum | J:62491 |
| Mgi Id | MGI:1858994 | Doi | 10.1016/s0304-3835(00)00386-4 |
| Citation | Iwase Y, et al. (2000) Inhibitory effect of flavonoids from citrus plants on Epstein-Barr virus activation and two-stage carcinogenesis of skin tumors. Cancer Lett 154(1):101-5 |
| abstractText | To search for possible anti-tumor promoters, thirteen flavones (1-13) obtained from the peel of Citrus plants were examined for their inhibitory effects on the Epstein-Barr virus early antigen (EBV-EA) activation by a short-term in vitro assay. Of these flavones, 3,5,6,7,8,3',4'-heptamethoxyflavone (HPT) (13) exhibited significant inhibitory effects on the EBV-EA activation induced by the tumor promoter, 12-O-tetradecanoylphorbol 13-acetate (TPA). Further, compound 13 exhibited remarkable inhibitory effects on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. |
