| Primary Identifier | IPR028660 | Type | Family |
| Short Name | SNX1 |
| description | Sorting nexin-1 (SNX1) belongs to the sorting nexin family, which contains a conserved PX (phox homology) domain that is responsible for binding to specific phosphoinositides []. SNX1 and SNX2 are orthologues of yeast Vps5, which is a component of retromer complex that is essential in endosome-to-Golgi retrograde transport []. The mammalian retromer complex is composed of the SNX1/SNX2 alternative heterodimer or homodimer and the Vps26-Vps29-Vps35 obligate heterotrimer []. Like SNX2, SNX1 also has an additional C-terminal BAR domain. SNX1 and SNX2 play interchangeable but essential roles in retromer structure and function [].SNX1 may have a role in sensing membrane curvature and inducing the formation of tubules [, ]. |
