| Type | MGI:General | Description | in control mice, the developmental switch from skeletal muscle end plate channels with low-to-high conductance is complete by P14-P16, but this switch does not occur in mutant mice and end plate channels remain with low conductance impairment of transmission by the mesure of the mean nerve deficit, calculated as the difference in tension time integrals at 100 Hz during muscle or nerve stimulation, is increased in mutant mice, and increases further with higher frequency of stimulation and with the number of stimuli during tetanic stimulation |
