| First Author | Berke JD | Year | 2001 |
| Journal | Neuron | Volume | 32 |
| Issue | 2 | Pages | 277-87 |
| PubMed ID | 11683997 | Mgi Jnum | J:67671 |
| Mgi Id | MGI:1931120 | Doi | 10.1016/s0896-6273(01)00465-2 |
| Citation | Berke JD, et al. (2001) Dopamine and glutamate induce distinct striatal splice forms of ania-6, an RNA polymerasse II-associated cyclin. Neuron 32(2):277-287 |
| abstractText | Control of neuronal gene expression by drugs or neurotransmitters is a critical step in long-term neural plasticity. Here, we show that a gene induced in the striatum by cocaine or direct dopamine stimulation, ania-6, is a member of a novel family of cyclins with homology to cyclins K/T/H/C. Further, different types of neurotransmitter stimulation cause selective induction of distinct ania-6 isoforms, through alternative splicing. The longer Ania-6 protein colocalizes with nuclear speckles and is associated with key elements of the RNA elongation/processing complex, including the hyperphosphorylated form of RNA polymerase II, the splicing factor SC-35, and the p110 PITSLRE cyclin-dependent kinase. Distinct types of neuronal stimulation may therefore differentially modulate nuclear RNA processing, through altered transcription and splicing of ania-6. |
