| Primary Identifier | MGI:2384974 | Organism | mouse, laboratory |
| Chromosome | 12 | NCBI Gene Number | 217721 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable heme binding activity and heme transmembrane transporter activity. Acts upstream of or within several processes, including brain development; endothelial tip cell fate specification; and in utero embryonic development. Predicted to be located in endoplasmic reticulum membrane and mitochondrial membrane. Predicted to be active in membrane. Is expressed in several structures, including central nervous system and yolk sac. Used to study proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome. Human ortholog(s) of this gene implicated in proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome. Orthologous to human FLVCR2 (FLVCR choline and putative heme transporter 2). PHENOTYPE: Mice homozygous for a null allele exhibit neonatal lethality, cyanosis, and impaired brain vasculature development. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
