| First Author | Belz GT | Year | 2007 |
| Journal | Nat Immunol | Volume | 8 |
| Issue | 10 | Pages | 1060-6 |
| PubMed ID | 17767161 | Mgi Jnum | J:125274 |
| Mgi Id | MGI:3758116 | Doi | 10.1038/ni1505 |
| Citation | Belz GT, et al. (2007) Minimal activation of memory CD8(+) T cell by tissue-derived dendritic cells favors the stimulation of naive CD8(+) T cells. Nat Immunol 8(10):1060-6 |
| abstractText | Of the many dendritic cell (DC) subsets, DCs expressing the monomorphic coreceptor CD8 alpha-chain (CD8alpha) are localized permanently in lymphoid organs, whereas 'tissue-derived DCs' remain in nonlymphoid tissues until they 'capture' antigen and then move to local lymph nodes. Here we show that after lung infection, both naive and memory CD8(+) 'killer' T cells responded to influenza virus antigens presented by lymph node-resident CD8alpha(+) DCs, but only naive cells responded to antigens presented by lung-derived DCs. This difference provides a mechanism for priming naive T cell responses in conditions in which robust memory predominates. Our findings have implications for immunity to pathogens that can mutate their T cell epitopes, such as influenza virus and human immunodeficiency virus, and challenge the long-held view that memory T cells have less-stringent requirements for activation than naive T cells have. |
