Primary Identifier | MGI:2385437 | Allele Type | Targeted |
Attribute String | Conditional ready, No functional change | Gene | Mdm2 |
Transmission | Germline | Strain of Origin | 129S7/SvEvBrd-Hprt1<+> |
Is Recombinase | false | Is Wild Type | false |
molecularNote | A construct, in which exons 5 and 6 were flanked by a loxP site in intron 4 and a floxed neo cassette in intron 6, was incorporated at the endogenous locus via homologous recombination. The floxed exons encode amino acids 53 through 113, which encompass most of the Trp53-binding domain. |