| First Author | Ozaki N | Year | 2000 |
| Journal | Nat Cell Biol | Volume | 2 |
| Issue | 11 | Pages | 805-11 |
| PubMed ID | 11056535 | Mgi Jnum | J:71886 |
| Mgi Id | MGI:2151174 | Doi | 10.1038/35041046 |
| Citation | Ozaki N, et al. (2000) cAMP-GEFII is a direct target of cAMP in regulated exocytosis. Nat Cell Biol 2(11):805-11 |
| abstractText | Although cAMP is well known to regulate exocytosis in many secretory cells, its direct target in the exocytotic machinery is not known. Here we show that cAMP-GEFII, a cAMP sensor, binds to Rim (Rab3-interacting molecule, Rab3 being a small G protein) and to a new isoform, Rim2, both of which are putative regulators of fusion of vesicles to the plasma membrane. We also show that cAMP-GEFII, through its interaction with Rim2, mediates cAMP-induced, Ca2+-dependent secretion that is not blocked by an inhibitor of cAMP-dependent protein kinase (PKA). Accordingly, cAMP-GEFII is a direct target of cAMP in regulated exocytosis and is responsible for cAMP-dependent, PKA-independent exocytosis. |
