| First Author | Morikawa Y | Year | 1996 |
| Journal | Biochem Biophys Res Commun | Volume | 226 |
| Issue | 1 | Pages | 107-12 |
| PubMed ID | 8806599 | Mgi Jnum | J:35287 |
| Mgi Id | MGI:82737 | Doi | 10.1006/bbrc.1996.1318 |
| Citation | Morikawa Y, et al. (1996) Expression of IL-3 receptor in testis. Biochem Biophys Res Commun 226(1):107-12 |
| abstractText | Interleukin-3 (IL-3) is a potent growth factor for hematopoietic cells. IL-3 transmits its signal through a specific cell surface receptor which consists of a primary binding alpha subunit (IL-3R alpha) and a signaling beta subunit that is shared by the IL-5 and GM-CSF receptors. Here, we describe the expression of the alpha and beta subunit of the IL-3 receptor in mouse testis and testicular cell lines both at nucleic acid and protein levels. Our data indicate that IL-3R alpha is expressed on the cell surface of testicular Leydig cells and a Leydig cell tumor cell line I-10. Expression of the beta subunit mRNA was only faintly detected in testis, but not in I-10 cells. Immunoelectron microscopy has revealed that IL-3R alpha is present on cell membrane and microvilli. |
