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Protein Coding Gene : Sdc2 syndecan 2
Primary Identifier  MGI:1349165 Organism  mouse, laboratory
Chromosome  15 NCBI Gene Number  15529
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Predicted to enable PDZ domain binding activity and identical protein binding activity. Involved in regulation of dendrite morphogenesis. Predicted to be located in neuronal cell body and plasma membrane. Predicted to be active in cell surface. Is expressed in several structures, including cranium; embryo mesenchyme; genitourinary system; jaw; and retina. Human ortholog(s) of this gene implicated in cleft lip and cleft palate. Orthologous to human SDC2 (syndecan 2).
PHENOTYPE: Mice homozygous for a null allele exhibit reduced angiogenesis and VEGFA165-induced endothelial cell proliferation and migration. [provided by MGI curators]
  • synonyms:
  • heparan sulfate proteoglycan 1, cell surface-associated (fibroglycan),
  • Hspg1,
  • Sdc2,
  • MGD-MRK-14687,
  • expressed sequence AA960457,
  • MGI:1921849,
  • 4833414L08Rik,
  • fibroglycan,
  • syndecan 2,
  • AA960457,
  • MGI:2145934,
  • MGD-MRK-10975,
  • Synd2,
  • MGI:96256,
  • RIKEN cDNA 4833414L08 gene
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2 Involved In Mutations

Trail: ProteinCodingGene

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Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

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Function

Mouse features --> Functions (GO terms)

Homology

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Interactions

27 Pathways

Trail: ProteinCodingGene

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Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

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