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Protein Coding Gene : Sgo1 shugoshin 1
Primary Identifier  MGI:1919665 Organism  mouse, laboratory
Chromosome  17 NCBI Gene Number  72415
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Predicted to enable kinase binding activity. Acts upstream of or within centriole-centriole cohesion. Located in kinetochore. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and heart. Human ortholog(s) of this gene implicated in chronic atrial and intestinal dysrhythmia. Orthologous to human SGO1 (shugoshin 1).
PHENOTYPE: Mice homozygous for a gene-trapped allele show prenatal lethality. Heterozygotes display enhanced chromosome instability, as well as increased formation of aberrant crypt foci and accelerated development of colon tumors after exposure to azoxymethane. [provided by MGI curators]
  • synonyms:
  • shugoshin 1,
  • Sgo1,
  • expressed sequence C81037,
  • shugoshin-like 1 (S. pombe),
  • 3300001M08Rik,
  • C81037,
  • MGI:2147138,
  • RIKEN cDNA 3300001M08 gene,
  • Sgol1
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Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

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Mouse features --> Functions (GO terms)

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Interactions

18 Pathways

Trail: ProteinCodingGene

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Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

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