| Primary Identifier | MGI:1859866 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 107995 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable several functions, including anaphase-promoting complex binding activity; histone deacetylase binding activity; and ubiquitin ligase activator activity. Involved in metaphase/anaphase transition of meiosis I; positive regulation of synapse maturation; and positive regulation of synaptic plasticity. Acts upstream of or within mitotic sister chromatid cohesion; mitotic spindle assembly; and regulation of meiotic nuclear division. Located in centrosome and kinetochore. Is expressed in several structures, including brain; early conceptus; female reproductive system; hemolymphoid system; and trigeminal ganglion. Orthologous to human CDC20 (cell division cycle 20). PHENOTYPE: Mice homozygous for mutations in this gene display embryonic lethality with cell cycle abnormalities. Mice heterozygous for a mutation in this gene display increased tumor incidence and increased incidence of aneuploidy. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
