| Primary Identifier | MGI:2386258 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 170720 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable CARD domain binding activity. Predicted to be involved in negative regulation of apoptotic process; positive regulation of protein phosphorylation; and tumor necrosis factor-mediated signaling pathway. Predicted to act upstream of or within apoptotic process. Predicted to be located in aggresome and cytosol. Predicted to be active in cytoplasm. Is expressed in gut; nose; and vibrissa. Used to study psoriasis 2. Human ortholog(s) of this gene implicated in pityriasis rubra pilaris and psoriasis 2. Orthologous to human CARD14 (caspase recruitment domain family member 14). PHENOTYPE: Homozygous null mice show resistance to IMQ-induced psoriasiform disease. Heterozygotes for a gain-of-function allele develop chronic psoriasis with scaly lesions, epidermal thickening, keratinocyte hyperproliferation, hyperkeratosis and skin inflammation while homozygotes die within days of birth. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
