| Primary Identifier | MGI:2669987 | Allele Type | Chemically induced (ENU) |
| Gene | Ikzf1 | Inheritance Mode | Recessive |
| Strain of Origin | C57BL/6JSfdAnu | Is Recombinase | false |
| Is Wild Type | false | Project Collection | APF ENU Mutagenesis |
| molecularNote | A transition point mutation (A to G) at position 572 resulted in a histidine to arginine missense mutation at codon 191 (H191R). The substitution disrupts the conserved Cys2His2 unit that tetrahedrally coordinates a zinc ion between the anitparallel beta sheet and alpha helix of the zinc finger. DNA binding is putatively disrupted by the interference of the tertiary structure of the N-terminal of zinc finger 3. A full length protein that assembles into higher order complexes is produced from this allele. |
