| First Author | Shaham L | Year | 2012 |
| Journal | Leukemia | Volume | 26 |
| Issue | 9 | Pages | 2011-8 |
| PubMed ID | 22456625 | Mgi Jnum | J:192062 |
| Mgi Id | MGI:5463866 | Doi | 10.1038/leu.2012.90 |
| Citation | Shaham L, et al. (2012) MiR-125 in normal and malignant hematopoiesis. Leukemia 26(9):2011-8 |
| abstractText | MiR-125 is a highly conserved microRNA throughout many different species from nematode to humans. In humans, there are three homologs (hsa-miR-125b-1, hsa-miR-125b-2 and hsa-miR-125a). Here we review a recent research on the role of miR-125 in normal and malignant hematopoietic cells. Its high expression in hematopoietic stem cells (HSCs) enhances self-renewal and survival. Its expression in specific subtypes of myeloid and lymphoid leukemias provides resistance to apoptosis and blocks further differentiation. A direct oncogenic role in the hematopoietic system has recently been demonstrated by several mouse models. Targets of miR-125b include key proteins regulating apoptosis, innate immunity, inflammation and hematopoietic differentiation. |
