Primary Identifier | MGI:108390 | Organism | mouse, laboratory |
Chromosome | 13 | NCBI Gene Number | 16563 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0) Predicted to enable several functions, including ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Involved in dendritic transport. Located in sperm principal piece. Is active in GABA-ergic synapse. Is expressed in central nervous system and dorsal root ganglion. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations 3. Orthologous to human KIF2A (kinesin family member 2A). PHENOTYPE: Homozygous null mice display neonatal lethality, abnormal lamination of the cerebral cortex, hippocampus and cerebellum, impaired neuronal migration, and abnormal axon outgrowth. [provided by MGI curators] |