| First Author | Ye TZ | Year | 2000 |
| Journal | Gene | Volume | 242 |
| Issue | 1-2 | Pages | 337-45 |
| PubMed ID | 10721728 | Mgi Jnum | J:60243 |
| Mgi Id | MGI:1353084 | Doi | 10.1016/s0378-1119(99)00516-8 |
| Citation | Ye TZ, et al. (2000) Ermap, a gene coding for a novel erythroid specific adhesion/receptor membrane protein. Gene 242(1-2):337-45 |
| abstractText | Ermap (erythroid membrane-associated protein), a gene coding for a novel transmembrane protein produced exclusively in erythroid cells, is described. It is mapped to murine Chromosome 4, 57 cM distal to the centromere. The initial cDNA clone was isolated from a day 9 murine embryonic erythroid cell cDNA library. The predicted peptide sequence suggests that ERMAP is a transmembrane protein with two extracellular immunoglobulin folds, as well as a highly conserved B30.2 domain and several phosphorylation consensus sequences in the cytoplasmic region. ERMAP shares a high homology throughout the entire peptide with butyrophilin, a glycoprotein essential for milk lipid droplet formation and release. A GFP-ERMAP fusion protein was localized to the plasma membrane and cytoplasmic vesicles in transiently transfected 293T cells. Northern blot analysis and in-situ hybridization demonstrated that Ermap expression was restricted to fetal and adult erythroid tissues. ERMAP is likely a novel adhesion/receptor molecule specific for erythroid cells. |
