| Primary Identifier | IPR016295 | Type | Family |
| Short Name | Proteasome_beta4 |
| description | This group represents the beta type-4 subunit (MEROPS identifier T01.987) from the proteasome endopeptidase complex, which is one of the non-peptidase subunits. This subunit is known as beta type-7 in fungi.The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of non-lysosomal protein degradation in both the cytosol and nucleus []. It is composed of 28 subunits arranged as four homoheptameric rings that stack on top of one another forming an elongated α-β-beta-alpha cylinder with a central cavity [, ]. The proteasome alpha and beta subunits are members of the N-terminal nucleophile (Ntn)-hydrolase superfamily []. Three of the beta subunits (beta1, beta2 and beta5) have an N-terminal threonine residue exposed as a nucleophile in peptide bond hydrolysis []. Eukaryotes have 7 alpha and 7 beta proteasome subunits while archaea have one of each []. |
