| First Author | Tang Y | Year | 2003 |
| Journal | Science | Volume | 299 |
| Issue | 5606 | Pages | 574-7 |
| PubMed ID | 12543979 | Mgi Jnum | J:81747 |
| Mgi Id | MGI:2449899 | Doi | 10.1126/science.1075994 |
| Citation | Tang Y, et al. (2003) Disruption of transforming growth factor-beta signaling in ELF beta-spectrin-deficient mice. Science 299(5606):574-7 |
| abstractText | Disruption of the adaptor protein ELF, a beta-spectrin, leads to disruption of transforming growth factor-beta (TGF-beta) signaling by Smad proteins in mice. Elf-/- mice exhibit a phenotype similar to smad2+/-/smad3+/- mutant mice of midgestational death due to gastrointestinal, liver, neural, and heart defects. We show that TGF-beta triggers phosphorylation and association of ELF with Smad3 and Smad4, followed by nuclear translocation. ELF deficiency results in mislocalization of Smad3 and Smad4 and loss of the TGF-beta-dependent transcriptional response, which could be rescued by overexpression of the COOH-terminal region of ELF. This study reveals an unexpected molecular link between a major dynamic scaffolding protein and a key signaling pathway. |
