| Primary Identifier | IPR023167 | Type | Homologous_superfamily |
| Short Name | Yap1_redox_dom_sf |
| description | The transcription factor Yap1 is a central regulator of the response to oxidative stress in Saccharomyces cerevisiae. In the active oxidized form, a nuclear export signal (NES) in the carboxy-terminal cysteine-rich domain is masked by disulphide-bond-mediated interactions with a conserved amino-terminal α-helix. Upon reduction of the disulphide bonds, Yap1 undergoes a change that exposes the NES and allows redistribution to the cytoplasm []. This entry represents a redox-regulated domain superfamily of Yap1. |
