| First Author | Chou-Green JM | Year | 2003 |
| Journal | Physiol Behav | Volume | 78 |
| Issue | 4-5 | Pages | 641-9 |
| PubMed ID | 12782219 | Mgi Jnum | J:96440 |
| Mgi Id | MGI:3530437 | Doi | 10.1016/s0031-9384(03)00047-7 |
| Citation | Chou-Green JM, et al. (2003) Compulsive behavior in the 5-HT2C receptor knockout mouse. Physiol Behav 78(4-5):641-9 |
| abstractText | The efficacy of serotonergic pharmacotherapy indicates that serotonin (5-HT) plays a role in the treatment, if not the etiology, of obsessive-compulsive disorder (OCD). While some clinical evidence implicates 5-HT(2C) receptors in this disorder, a definitive function has yet to be validated. We hypothesized that 5-HT(2C) receptor knockout (KO) mice may display compulsive-like behavior. This paper describes characterization of several distinct, highly organized behaviors in mice lacking functional 5-HT(2C) receptors, which supports a compulsive-like syndrome.Compulsive-like behavior was assessed in male 5-HT(2C) receptor KO and wildtype (WT) mice. Chewing of non-nutritive clay, chewing patterns on plastic-mesh screens, and the frequency of head dipping were measured. 5-HT(2C) receptor KO mice chewed more clay, produced a distinct pattern of 'neat' chewing of plastic screens and exhibited reduced habituation of head dipping activity compared to WT mice. We conclude that the 5-HT(2C) receptor null mutant mouse provides a promising model of compulsive behavior and a means to further explore the role of 5-HT in OCD. |
