| First Author | Kuwahara A | Year | 2010 |
| Journal | Development | Volume | 137 |
| Issue | 7 | Pages | 1035-44 |
| PubMed ID | 20215343 | Mgi Jnum | J:158681 |
| Mgi Id | MGI:4439428 | Doi | 10.1242/dev.046417 |
| Citation | Kuwahara A, et al. (2010) Wnt signaling and its downstream target N-myc regulate basal progenitors in the developing neocortex. Development 137(7):1035-44 |
| abstractText | Basal progenitors (also called non-surface dividing or intermediate progenitors) have been proposed to regulate the number of neurons during neocortical development through expanding cells committed to a neuronal fate, although the signals that govern this population have remained largely unknown. Here, we show that N-myc mediates the functions of Wnt signaling in promoting neuronal fate commitment and proliferation of neural precursor cells in vitro. Wnt signaling and N-myc also contribute to the production of basal progenitors in vivo. Expression of a stabilized form of beta-catenin, a component of the Wnt signaling pathway, or of N-myc increased the numbers of neocortical basal progenitors, whereas conditional deletion of the N-myc gene reduced these and, as a likely consequence, the number of neocortical neurons. These results reveal that Wnt signaling via N-myc is crucial for the control of neuron number in the developing neocortex. |
