| First Author | Max EE | Year | 1981 |
| Journal | J Biol Chem | Volume | 256 |
| Issue | 10 | Pages | 5116-20 |
| PubMed ID | 6262318 | Mgi Jnum | J:32362 |
| Mgi Id | MGI:79861 | Doi | 10.1016/s0021-9258(19)69374-9 |
| Citation | Max EE, et al. (1981) The nucleotide sequence of a 5.5-kilobase DNA segment containing the mouse kappa immunoglobulin J and C region genes. J Biol Chem 256(10):5116-20 |
| abstractText | We have determined the nucleotide sequence of a 5.5-kilobase segment of cloned mouse DNA which includes regions encoding two parts of the mouse kappa immunoglobulin gene: the J regions (amino acids 96-108 of the kappa chain) and the C region (residues 109-214). This sequence allows us to rule out interruptions in the germline constant region coding segment as well as the presence of additional functional J genes in the sequenced DNA segment, although two weak homologies to J regions have been found. The complete sequence also allows us to identify a single occurrence of the heptanucleotide palindrome thought to play a role in V/J joining. This palindrome, midway between J and C regions, is the site of aberrant joining in the plasmacytoma MPC11 and may be a target for such aberrant recombination of other kappa genes. In addition, computer analysis of the J sequences suggests that those closest to the C region arose by the most recent duplication event. |
