| First Author | Suzuki K | Year | 1998 |
| Journal | FEBS Lett | Volume | 433 |
| Issue | 1-2 | Pages | 1-4 |
| PubMed ID | 9738920 | Mgi Jnum | J:49430 |
| Mgi Id | MGI:1277475 | Doi | 10.1016/s0014-5793(98)00856-4 |
| Citation | Suzuki K, et al. (1998) A novel aspect of calpain activation. FEBS Lett 433(1-2):1-4 |
| abstractText | Calpain, a Ca2+-dependent biomodulator, alters the properties of substrate proteins by cleaving them at a limited number of specific sites. Recent studies of the structure-function relationship of calpain and X-ray analysis of its Ca2+-binding domain have revealed hitherto unknown features of the regulation of calpain activity. A novel dissociation/autolysis mechanism for the activation of calpain at the membrane is proposed, which incorporates recent findings from structure-function studies of calpain, and its implications are discussed. |
