| First Author | Wulf P | Year | 1999 |
| Journal | Brain Res Dev Brain Res | Volume | 116 |
| Issue | 2 | Pages | 169-80 |
| PubMed ID | 10521561 | Mgi Jnum | J:57625 |
| Mgi Id | MGI:1345019 | Doi | 10.1016/s0165-3806(99)00092-9 |
| Citation | Wulf P, et al. (1999) Embryonic expression of epithelial membrane protein 1 in early neurons. Brain Res Dev Brain Res 116(2):169-80 |
| abstractText | Epithelial membrane protein 1 (EMP1) is a member of the peripheral myelin protein 22 (PMP22) family. This family is best known for the crucial contribution of PMP22 to the development and maintenance of the peripheral nervous system (PNS). PMP22 is widely expressed, with highest levels in myelinating Schwann cells, and mutations affecting the PMP22 gene lead to PNS-restricted neuropathies. We have investigated the spatio-temporal distribution of EMP1 and compared it to that of PMP22. We found that EMP1 and PMP22 mRNA are most conspicuously expressed in the prenatal mouse brain during neurogenesis. In the developing forebrain, we localized EMP1 mRNA and protein to the first set of neurons that are generated and leave the ventricular zone to form the preplate. Later in development, EMP1 was found in derivatives of the preplate, the marginal zone and the subplate. Reduced expression was observed in the newly generated cortical plate neurons. In other parts of the developing CNS and PNS, EMP1 was also detected in early neurons and along the initial fiber tracts. Furthermore, EMP1 was highly expressed by immature neurons in embryonal dorsal root ganglia-explant cultures and in neuroectodermal differentiated P19 cells. While PMP22 functions mainly in Schwann cell growth and differentiation, the spatio-temporal localization of EMP1 suggests a role in neuronal differentiation and neurite outgrowth. |
