| First Author | Adler ID | Year | 1994 |
| Journal | Mutat Res | Volume | 307 |
| Issue | 1 | Pages | 237-43 |
| PubMed ID | 7513802 | Mgi Jnum | J:33804 |
| Mgi Id | MGI:81281 | Doi | 10.1016/0027-5107(94)90297-6 |
| Citation | Adler ID, et al. (1994) Clastogenicity of trophosphamide in somatic and germinal cells of mice. Mutat Res 307(1):237-43 |
| abstractText | Trophosphamide, a chemotherapeutic agent structurally related to cyclophosphamide, was tested in the micronucleus and heritable translocation assays in mice. It induced a linear increase of micronuclei in polychromatic erythrocytes 24 h after treatment with 1, 5, 25 or 50 mg/kg. In spermatids and spermatozoa of mice heritable translocations were induced by 150 mg/kg with an average frequency of 6%. The doubling doses calculated for micronucleus induction and heritable translocation induction were 5.0 and 1.3 mg/kg, respectively. These values are in the same order of magnitude and suggest that somatic and germinal cells are similarly sensitive to the clastogenic action of trophosphamide. |
