Primary Identifier | MGI:97598 | Organism | mouse, laboratory |
Chromosome | 14 | NCBI Gene Number | 18753 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0) Enables diacylglycerol-dependent serine/threonine kinase activity and insulin receptor substrate binding activity. Involved in several processes, including negative regulation of cellular component organization; negative regulation of insulin receptor signaling pathway; and negative regulation of platelet aggregation. Acts upstream of or within B cell proliferation; immunoglobulin mediated immune response; and positive regulation of apoptotic signaling pathway. Located in several cellular components, including cell-cell junction; cytoplasm; and nuclear matrix. Is expressed in several structures, including alimentary system; central nervous system; early embryo; genitourinary system; and heart and pericardium. Human ortholog(s) of this gene implicated in autoimmune lymphoproliferative syndrome type 3; hypertension; and steatotic liver disease. Orthologous to human PRKCD (protein kinase C delta). PHENOTYPE: Mice homozygous for a null allele exhibit decreased neutrophil cell numbers and activity, increased B cell numbers and proliferation, increased acute inflammation, and increased IgG1 and IgA serum levels. [provided by MGI curators] |