| First Author | Song HK | Year | 2007 |
| Journal | J Am Soc Nephrol | Volume | 18 |
| Issue | 10 | Pages | 2672-82 |
| PubMed ID | 17855646 | Mgi Jnum | J:129782 |
| Mgi Id | MGI:3770176 | Doi | 10.1681/ASN.2006101076 |
| Citation | Song HK, et al. (2007) Origin and fate of pendrin-positive intercalated cells in developing mouse kidney. J Am Soc Nephrol 18(10):2672-82 |
| abstractText | Pendrin is an apical anion exchanger found in type B and nonA-nonB intercalated cells that is involved in bicarbonate secretion. The purpose of this study was to establish the origin and fate of pendrin-positive intercalated cells in the mouse kidney. Using immunohistochemistry, we found that pendrin-positive cells first appeared in the connecting tubule at embryonic day 14 (E14) and subsequently in the medullary collecting duct at E18. Most of the pendrin-positive cells in the connecting tubule were nonA-nonB intercalated cells, wheras those in the medullary collecting duct were type B intercalated cells. In the cortical collecting duct, pendrin-positive cells appeared in the inner part at day 4 after birth and in the outer part at day 7. Pendrin-positive cells gradually disappeared by apoptosis from the inner part of the medullary collecting duct two weeks after birth. Using 5-bromo-2'deoxy-uridine (BrdU) to follow cell proliferation, we determined that selective proliferation of pendrin-positive intercalated cells does not occur; instead, these cells may arise from undifferentiated precursor cells from separate foci, one in the connecting tubule and one in the collecting duct. |
